I have a UX1 which I run normally on a small mobile rig using either it to drive podfarm2 or the saffire6 usb interface I have.
Latest software from Line6 allows you to use ANY USB interface, which is cool.
But I also use the UX1 in conjunction with an RME HDSP 9652 in my main machine with no issues.
It really does look like the answer lies somewhere in the USB vs firewire chain.
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