I've used Reaper with both a Macbook Pro and a Win7 PC.
OSX pros: OSX uses ASIO or something similar by default, so no need to monkey about with sound drivers
OSX cons: the plugin selection is inferior - there are plenty of plugins that work with OSX, but it's unavoidable that you'll find some which you really want to use but can't because they are Windows only. I also had a lot of trouble with plugin GUI not drawing correctly in Reaper.
Win7 pros: tons of awesome free plugins to perform almost any function
Win7 cons: adding the additional layer of complexity by requiring non-default audio drivers opens up the potential for setup errors that can cause sound quality issues like distortion, cracking and popping sound output. Although I prefer Win7 overall, I am struggling with this issue which was never a consideration while I was using OSX.
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