Lots of good suggestions here.
Some amps just have that fuzzy sound, especially digital models. Sometimes aliasing is also a problem. One thing that can help the tone is cutting and boosting before/after the amp, this way you have more control over how the drive sounds. One big part of a guitar sound is certainly the rather steep low pass filter/cabinet after the distortion.
Also depending on the material, you could try playing each note of a chord separately. That reduces IMD and thus gives you clearer sound.
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