Hi I have 120 + track orchestral projects and have similar problems.
For me it seems to have to do with RAM issues - if you are usinf R64 and have 32 bit plugs the plugs run in separate processes which are less than 2G - running near full causes CPU load seemingly unrelated to plugin use.
likewise routed automation can start to bog things down.
Justin mentioned elsewhere that bridged plugs add overhead.
I have had better results running in 32 bits...
in nay case watch reapers ram size - one of my plugs sometimes leaks memory for instance. plus certain plugs (Kontakt!) have some settings re: memory use that can be retarded.
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