From their webpage:
"Standard MIDI control is tunnelled over the USB connection so you can easily map the faders to the tracks of your favourite DAW. A DAW Control driver is [also] available for easy setup and emulation of HUI or Mackie Control protocols on Mac OS X systems [should you choose to use it that way instead]."
Looks like a simple 'yes' and it's really plug and play.
Reaper is listed ahead of Protools now...
"The interface is class-compliant on Mac OS X – truly plug ‘n play. It will be recognized straightaway by any DAW supporting Core Audio, including Logic, Cubase, Reaper, and Pro Tools."
Haha. Digital mixing board makers are seeing the writing on the wall and turning their mixers into also being straight audio/MIDI interfaces for those of us mixing with a DAW (live or studio). Nice save. I was wondering how this would play out.