Maybe he's configured to open the last project on start, and isn't getting the chance to disable the FX before he opens it? (I can't remember where that setting is, but it's a good one to disable IMO)
Try starting Reaper through the Start Menu -> Programs -> Reaper -> REAPER (create new project) - see if it opens up with all default settings, no tracks.
If it opens .. you know it's your project. Without closing REAPER, open your project through the File menu, and notice in the dialogue window where you choose the file to open, there will be an check-able option in that window for opening the project with all the FX offline.
Start there .. it'll tell you if it's the project, and whether or not it's a plugin. Good luck!
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R. Smith :: Jim Death Presents
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