As far as I know, Alesis dont supply an ASIO driver with your unit, so in order to get rid of what SOUNDS like your computer and interface not being able to cope with your current settings, you might want to download and install the free ASIO4ALL.
Once you have installed it, go into your reaper preferences and in the Audio Device section you should now be able to select ASIO as your preferred driver.
It will then be up to you to play with buffer settings in ASIO4ALL till you get a good balance between no dropouts and not too much latency (delay between what you sing/play and hearing it in your headphones) which might take a while to figure out but well worth it.
And of course come back and ask for more help if you need it, any time.
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