This is almost surely some weird setup you have.
1. Open a new project.
2. Put a noise generator plugin(some come with reaper) on a track
3. You should hear stereo output. Make sure you don't have mono selected on master.
4. Make sure all pans are 0 and all widths are 100%
5. Make sure your master IO's are all set correctly.
6. Check your panning and see if everything works.
If it works, then it's your project that has something off. It is a width, pan, mono, etc...
If it doesn't work then it's a hardware issue. You could have your "asio"(or MME or whatever) settings to use only one output(I know you said you have it using 1&2 so this doesn't apply to you specifically), or could have a bad cable or whatever.
You should be able to trouble shoot this type of problem in about 5 mins. It's one of those things that is either X or Y but not both, and hence try to narrow it down by testing X or Y independently.
I remember having a similar problem and it was due to setting the width or something. It was pretty obvious once I figured it out.
Usually when the panning acts like you have described, it's due to the left channel not working and the mix at some point being mixed to mono.
e.g., you don't have your headphone jack plugged in all the way. The L channel doesn't make contact to the tip, but the Right channel makes contact both the tip and ring. This makes the headphones sound in mono for just the Right channel. When you pan left, you are removing the right and hence, because the headphones are only "hearing" right, it acts as a volume.
Again, you should be able to figure this stuff out without too much problem. If reaper is showing that the panning and everything is working, then chances are it's not reaper. Hence looking after it, like if the MOTO has a mixer interface, or the jacks on the interface, etc.
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