I am also suffering from crackling with my RME HDSP 9632 at 88.2 kHz / 512 samples, Windows 7 x64 w/ i7 3.4 GHz CPU and 24 GB RAM, when there are a lot of FX being processed (Reaper reports 25 FX, CPU load is only ~12% though). I have to increase the latency to avoid crackles. I have Reaper 4.13 x64.
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