That sounds like a fair suggestion regarding REAPER and pin connections.
On that topic, I do recall one more thing that may be relevant in reproducing the bug I am seeing. When I'm using the other multichannel VSTs, I do change around the pin assignments. I'm using a 3D cube monitoring array but I still have center and LFE, channel assignments in my setup so I repatch everything to skip pins 2 and 3 (which are C and LFE).
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