I'm using:
wine-4.10 (Staging) on Kubuntu (lowlatency) testing this distro now. So far, very good.
I followed this install guide:
https://wiki.winehq.org/Ubuntu
I think I had some problem with wine-rt for couple of month ago and changed to Wine Staging. All problems was solved.
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OS: Manjaro KDE Plasma, Reaper For Linux (64Bit) native linux-vst plugins, LSP-Plugins, TpL-Plugins, Harrison's AVA & VST Plugins. Behringer U-PHORIA UMC22.
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