I didn't have TotalMix with my old RME 9636, but did with the FF400. I preferred PatchMix on the Emu though - I wish they hadn't killed that - although I have never tried the new RME interfaces with built in FX.
Anyway I understand you are attempting to highlight an area of superiority for OSX with this aggregate device thing. You must not be aware that you can combine devices using Asio4All. It's not magic software written - as all magic software is - by Apple, but it works.
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