Correct.
You can have any number of audio interfaces connected to the computer. The device or aggregate device you select in Reaper is the I/O that gets used.
PCI "sound card" interfaces and interfaces built into the logic board are still just audio interfaces. No different from USB/firewire/thunderbolt connected interfaces in general concept.
When rendering ITB, any connected audio interface has no bearing on the mix. If you are running external fx live and need to render the mix in real time with your external gear connected through your interface, now your connected interface becomes part of the equation.
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