If you have a sample rate of 44.1k, that means the Nyquist frequency is 22050 Hz. Anything above those frequencies will be reflected DOWN into the audible range, unless the plugin is doing oversampling and/or bandlimiting. In case of oversampling the plugin CAN produce frequencies above Nyquist, but before the signal is sent back to the host, it is downsampled to the host sample rate, in effect eliminating those higher frequencies.
Read up on aliasing, oversampling and bandlimiting.
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