It might be helpful to know what 32 bit "Synth plug" we are talking about. I use quite a few and have no problems.
Do you see the yellow "audio" lines in the meters as well as the red MIDI line? If not then the synth is not responding to the channel data you're sending. It's not as simple as the volume control inside the synth turned right down is it?
Have you tried setting Input to MIDI- All Inputs, All Channels to if anything is different?
Does that synth work with the internal Virtual Keyboard? Set to MIDI channel 5 or any other channel?
Steve
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