The OP question has a simple answer.
Any time you’re rendering anything that’s not your final mastered distribution file - if you’re ever going to do any more processing at all even if it’s simple volume adjustment - render to a floating point format and the same sample rate it was recorded at.
Floating point means you don’t have to worry about the dynamic range so you know that whatever happens you’re not going to clip or add noise. Sample rate conversion always causes some artifacts which can be accentuated by further processing. If your ME is going to do something that could cause aliasing, it’s their job to deal with it.
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