may be this will helpful for someone , my system is vista mbox2 and reaper 4.22.
here is how I solved my problem entirely in reaper ,
in preferences first you have to check "request sample rate" to 48000 and this is not gonna work but when you return preferences and uncheck this setting "request sample rate", somehow audio settings remain in 48000 sample rate and bingo !!! all crackling sound when recording gone.I'm happy with it now.
regards
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