I think it might also be lucky to use only vsts and reaper,
no plugins with java, carla, lv2, ladspa etc, and try other effects
than zyn, like the Dragonfly and zita reverbs, and vst versions of the
mda, drow and zam collections. Search vst in synaptic for more
linux vsts, assuming kx-repos are enabled. Citing the old
theory, 'too many cooks spoil the broth'
If that does not help, at least you'll have seen more options
for future use.
Cheers
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