I was pretty devastated when I lost the use of Opcode Vision. It's still out there somewhere, but I'm not going back to Mac, and Apple has a way of changing their OS so that nothing works anymore and you have to buy all new software, so I'm not sure it would even run unless I can find on old G3 in somebody's closet.
Windows also occasionally messes enough things up in an OS update to where we can't actually be confident that today's version of Reaper will work on Windows 12. Course, I'm still running two XP machines...
