Does everything work fine when using on board sound rather than the Focusrite?
And, do you have reaper open when you're having problems with chrome, or does it happen with reaper closed?
Regarding tweaks: Stuff that works now might not work in future versions of windows.
Like recently when people who had manually disabled bing search in cortana, who ended up with the cortana process using half their CPU power after updating to 1903, which assumed it would be turned on, and failed badly when it wasn't.
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