Also encountering this problem with OS X 10.10.5, Reaper 5.1 (rev 4ff7e5). Mainly happening with Izotope RX 4 Denoiser, I think because of the automation (automating "Reduction Amount"), but haven't played around too much with other fx. Every time I start and stop playback it logs another action in Undo History ("Edit FX parameter: Izotope RX Denoiser") even though I made no such changes to the parameter. Makes it hard to use the undo function anymore. It does not appear to be happening in Reaper 4.77.
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