Awhile ago, I ran a Presonus S1 demo project in S1 v3, on my macbook retina 2015, 16 gig ram, core i7.
It "only" contained S1 native plugins.
Result: Instant crackling and tearing sound at first play.
(And beware: my osx system on my macbook is very clean and well maintained)
Way to go Presonus.
If you are used to the excellent performance hit in Reaper, you won't take less in other DAW's.
Just my 2 cents.
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