We at ultraschall.fm use them successfully on Win and Mac.
If you use the Set-function, it will be written into reaper.ini, BUT Reaper will not recognize them until you restart Reaper.
That's why setting the ConfigVar and the entry in reaper.ini is helpful.
The ConfigVar to have it right away, the entry in reaper.ini to have it also after restart.
Otherwise, you would need to restart Reaper for changes to take effect.
Regarding the path-structure, just use the get_ini_file(), GetExePath() and GetResourcePath() functions and you are on the same side, no matter if it's a portable or a "stationary" installation.
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