Have you tried bit depth settings other than "32"? That's unnecessary. 24-bit is more than enough, and 32-bit for that device won't provide any additional benefit (it'll only take up more drive space for the recorded files).
It's possible that it will only work in 16-bit and 24-bit recording modes.
Also I use priority of 30 (modified from the default setting to help a bit with performance). I don't think "0" is a good setting, necessarily.
Plus that blocksize is a bit high. I'm using 64 (and 5 blocks) at 44.1 KHz and it's solid as anything. With my 2i2 that is.
You can also try setting it to 2 in / 2 out as a test, if that affects anything for some reason. Just to help eliminate variables.
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