Hi !
I use the very same setup as you:
- OSX 10.9.4.
- latest driver Motu pci-e. (i use a Motu 2408 MKiii audio interface)
- Latest version of Reaper (64bit)
- Samplerate: 44.1 khz
- Bitdepth: 24bit
- AudioBuffer: 512
I experience NO audio playback problems at all with this setup and settings in Reaper.
But then again, i don't use Rea insert at all.
Sorry to not be able to help you any further.
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