Check MacOS's own activity monitor, as there could be other processes on the system which is using CPU time.
And set your buffer to 512 with Request from interface selected, and put those other aggressive settings back to normal as it's overkill - t could be that you have the buffer on a strange setting or those more aggressive settings could making the issue worse, 512 should be fine for live, the actual latency is reported at the top of the Reaper bar for reference.
Which plugin are you using, and is it au or vst version?
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