It can make a difference if you monitor through Reaper and there's any latency but otherwise no, it's very common to raise the buffer size as a project grows. It's a tradeoff between latency and CPU usage, so set it as needed (smaller buffer = lower latency & more CPU usage)
When monitoring with any latency there is a tendency to start playing a little early so the sound arrives at your ears on time (this happens unconsciously), but without also turning on "Preserve PDC delayed monitoring..." option for the track your track will also playback a bit early.
So if the timing sounds off on playback, try that option.
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