Since I updated to the latest stable version (4.731 x64 win 7), I am noticing that when I turn on Loop mode in the main transport, and restart Reaper, that its turned off again.
Add to this the fact that whatever screenset I was using isnt restored correctly on restart (see
http://forum.cockos.com/showthread.php?t=137162), and now it means every time I launch Reaper I have to press F7 several times AND re-enable loop mode.