You probably need to first boot Focusrite's Mix Control software (of which there's a brand new update for most models), then, as serr says, make it change from the default system in & out to the Scarlett in Reaper's preferences (Audio/device). I don't think you need to get the Scarlett up in Apple's Audio Midi Setup, but if you don't get it in the available devices open Audio Midi Set up and make sure it shows up there and select it as your current interface. I don't think I've ever had to do that with my Scarlett except for when I've used other interfaces in between, but it wouldn't hurt to check. Pretty sure that GarageBand is defaulting to your last setup while Reaper is defaulting to its default before being set up to use the Scarlett.
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