Hmm.. I ask because I think it's asking for compatibility problems. I can easily run 64 samples latency with i7 and USB2 and record 22 simultaneous tracks at higher latencies - maybe more but that is all the inputs I have.
I could potentially handle lower than 64 samples, but my Fireface UFX doesn't go any lower. That being said IME the better sound card will likely get you better latency than the protocol used.
Not harping on RME I just know they do very good at this, hence my results above where other cheaper sound cards depend on more class compliant/rebranded drivers which tend to be slower and cause more issues.