I'm currently running Big Sur 11.6. When I first converted to Big Sur (was it a year ago?) I lost a small number of unsigned 3rd party plugins. I think I had to update my FocusRite software.
Big Sur will give you a security challenge on initial installs of some plugins, but that's easy enough to click through. Every so often I might find an older unsupported VST that doesn't work. In general I have zero problems with Big Sur.
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