Yeah, you need an interface simply with enough outputs. If you only have a stereo pair of outputs for example, then you would have to disconnect one of your monitors to use that output for the reamp output. Which you could still do, FYI!
Get an interface with more outputs and then you can leave your monitors hooked up.
A loopback feature returns an output from the computer to the loopback "input" channel of the interface. That lets you route audio elsewhere on the computer without using a virtual device. It's often redundant.
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