Hi, I don't have your audio interface, but I had some similar issues in the past.
I don't know on which computer you are working on, I had random glitches and crackles for no apparent reason, then I've found that after a motherboard bios update, the virtualization has been switched on by default and it was the cause for the glitches and after disabling it everything has been ok.
My suggestion is to check it inside your bios, it has a different name for Intel CPU and AMD, search for something like Intel VT, AMD-v or SVM.
IF virtualization is already disabled, you can also try to disable Hyper-Threading on intel CPU or SMT on AMD CPU, and also EIST on Intel CPU.
Also make sure that your operating system is using a high performance power plan and the CPU must always run at constant maximum frequency.
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