Some things to check in general:
- I'm assuming Windows 10 is 64-bit: did you install the Tools for UR 44
64-bit version?
https://www.steinberg.net/en/support...oads_ur44.html
- Have you already tried to install the latest ASIO driver from here?
https://www.steinberg.net/en/support...sb_driver.html
- Is using the UR44 as default playback device in Windows working?
- Can you select the UR44 as input/output when using WASAPI as audio system in Reaper (instead of ASIO)?