I had this the other day, using an extension cable for the headphones.its the adapter turned the stereo into a mono signal. Also check routing software that comes with your interface e.g motu gear comes with a software outside of reaper called cuemix, by default it may pan hard left and right inputs 1 and 2. You have to turn the channel to mono and centre. Doubt its anything in Reaper, generally these other factors are the cause.
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