Hi Justin,
Since around v1.05 I have been experiencing random crashes when altering Preference settings in REAPER. I now have a repeatable crash.
If I open and close the Preferences window more than 5 times in a row REAPER locks up and the only way to exit the program is to kill the process. I originally thought the crash had something to do with a VSTi being in the chain, but then I managed to crash it without anything in the Project by opening and closing the Preferences window as detailed above. For example:
and
and
Cheers,
Malcolm.