If you're looking for that big, thunderous bass guitar sound (assuming you have a clean DI), give this a try:
Duplicate the DI track, and label it "High." Label the original "Low." Add your favorite EQ (ReaEQ works a treat for this) and on the "high" track, add a high-pass filter (24dB/8ve works a treat!) somewhere between 125-160Hz. On the "low" track, add the same EQ (slope and knee frequency) but set it to low-pass. On the low track, add a comp, somehwere around 8:1, fast attack, slow release, dial it up for around 8-12dB of gain reduction, and normalize the volume. That should give you a REALLY solid, thick low-end on the bass. Adjust the knee frequencies on the two -pass filters to taste. On the high track, drop on an overdrive (TSE's "BOD" is a free emulation of the SansAmp bass driver and works pretty well for this), then a comp, 2.5:1-ish (medium-slow attack), max 6dB GR (leaves some dynamic life in the bass), EQ to taste, then drop on a stereo chorus to widen the bass out. The net result is that you have a juicy, wide, punchy mid and high with a nice growl to it, and an absolutely rock-solid low end that will just sit there against the kicks.
If you decide you need verb, I would leave the DI tracks alone, and just add it to the "amp" track.
And in answer to your original question, yes, it is best practice to keep the LF stuff in mono. The human ear is remarkably insensitive to directionality of low-frequency sound, to the point that below ~100Hz, you really can't tell where it's coming from. That's why mono subwoofers can be just about anywhere without affecting the stereo image. And that includes behind you! The LF content is also very sensitive to any sort of phase anomalies that stereo processing may introduce.
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