This issue seems to have reoccurred as described here:
https://forum.cockos.com/showthread.php?t=237124
my machine:
Reaper v6.45/win64 rev c64818
OS Name Microsoft Windows 10 Pro
Version 10.0.19042 Build 19042
Other OS Description Not Available
OS Manufacturer Microsoft Corporation
System Name TOBYAM
System Manufacturer System manufacturer
System Model System Product Name
System Type x64-based PC
System SKU SKU
Processor AMD Ryzen 9 5950X 16-Core Processor, 3401 Mhz, 16 Core(s), 32 Logical Processor(s)
BIOS Version/Date American Megatrends Inc. 3001, 12/4/2020
SMBIOS Version 3.3
Embedded Controller Version 255.255
BIOS Mode UEFI
BaseBoard Manufacturer ASUSTeK COMPUTER INC.
BaseBoard Product ROG STRIX X570-E GAMING
BaseBoard Version Rev X.0x
Platform Role Desktop
Secure Boot State Off
PCR7 Configuration Binding Not Possible
Windows Directory C:\WINDOWS
System Directory C:\WINDOWS\system32
Boot Device \Device\HarddiskVolume2
Locale United States
Hardware Abstraction Layer Version = "10.0.19041.1151"
User Name TOBYAM\TobyAM
Time Zone Pacific Standard Time
Installed Physical Memory (RAM) 64.0 GB
Total Physical Memory 63.9 GB
Available Physical Memory 46.1 GB
Total Virtual Memory 73.4 GB
Available Virtual Memory 50.8 GB
Page File Space 9.50 GB
Page File C:\pagefile.sys
Kernel DMA Protection Off
Virtualization-based security Not enabled
Device Encryption Support Reasons for failed automatic device encryption: TPM is not usable, PCR7 binding is not supported, Hardware Security Test Interface failed and device is not Modern Standby, Un-allowed DMA capable bus/device(s) detected, TPM is not usable
Hyper-V - VM Monitor Mode Extensions Yes
Hyper-V - Second Level Address Translation Extensions Yes
Hyper-V - Virtualization Enabled in Firmware Yes
Hyper-V - Data Execution Protection Yes